Hormone Therapy News Articles

Facts About HGH - The Human Growth Hormone

August 15th, 20011 | About HGH - HGH

HGH Oral or Nasal Spray?

Various forms of human growth hormone (HGH) allegedly being marketed as a nasal spray, oral spray, tablet, or capsule. In return, we merely state that the following problems must be addressed in valid scientific and legal terms before any such claims can be believed. HGH is large, fragile protein molecule with a molecular weight of 20,000. It contains 191 amino acids in an exact sequence. Its only source is from human genes, using very expensive and meticulous recombinant DNA technology. HGH from any other source, even from other animals, does not work in humans. There is no other source of HGH. There is absolutely no naturally occurring plant source of HGH. HGH must be made using human genetics. The only safe form of HGH is made by splicing human genes into cells and then multiplying those cells in a culture media. A protein molecule that large cannot penetrate intact membranes to any significant degree. Most would be wasted if it were used in a nasal spray or orally as a liquid.

Production costs of human growth hormone are high. HGH is so expensive that any waste is prohibitively expensive. The technology to make HGH is patented by large pharmaceutical companies and is restricted by law to their use. The HGH molecule loses potency very rapidly when dissolved in solution. The molecule is folded and twisted on itself repeatedly. Activity in the body depends on fragile cross linkages between branches of this very large molecule, which hold it in an exact three-dimensional configuration. It works on cell receptors exactly like a key in a lock. Any change in shape blocks HGH activity, even if the chemical formula remains exactly the same. Those cross-linkages break very easily and become unstable soon after dissolving in solution. Only with refrigeration can biological activity be maintained for up to two weeks. That's how fragile the growth hormone molecule is. How then could potency be maintained in a liquid spray?

For proper storage and shipping, HGH must be very carefully freeze-dried under a vacuum to become a powder. From most drug manufacturers even the powder form of growth hormone must also be kept refrigerated to maintain potency and activity. Only one large pharmaceutical company with research budgets in the billions of dollars has been able to solve that problem. HGH is classified as a pharmaceutical drug, strictly controlled by the FDA under state and federal laws and regulations. It is illegal to sell, prescribe, or dispense HGH except through a licensed pharmacy or clinic, and then only on a doctor's prescription in a bone fide doctor-patient relationship. To do otherwise is a criminal offense under the law.

Research studies proving benefit and safety have been published only for the injectable freeze-dried powder form of rHGH, taken by injection soon after dissolving in solution.

We will exam some HGH alternative product claims for efficacy:

HGH CLAIM: This is the first orally absorbed HGH, 191 amino acids (protein molecules) which are transported by a proprietary polymer matrix, allowing it to be absorbed in the oral mucosa and then transported directly to the Pituitary Gland.

HGH FACT: HGH has no beneficial effect to the pituitary gland itself. HGH has its effect elsewhere in the body. After entering the bloodstream, HGH very quickly attaches to receptors on cells throughout the body. The pituitary gland is the normal source of HGH in young adults. The pituitary releases HGH into the circulation so that it can have it's effects elsewhere.

HGH CLAIM: The oral HGH sprays avoid inactivation by the liver.

HGH FACT: When HGH is absorbed through the mucous membranes of the mouth or by injection it is handled in exactly the same way by the body. Only if absorbed through the lower intestine, as food is, would it go to the liver first through the portal venous system. One of the main reasons injectable HGH is the preferred administartion method is because the 20,000 molecular weight variant of HGH is too big to be absorbed or pass through the membranes in the mouth or underneath the tongue. Since HGH, a protein molecule, cannot penetrate through such intact membranes, most would be wasted if used through oral or nasal sprays.

HGH CLAIM: Until now, it has been virtually impossible to achieve oral absorption of the large HGH molecule. Previously, the only way was through injection into the bloodstream.

HGH FACT: Using patented technology, the pharmaceutical industry has developed ways to partially absorb some drugs through the skin. But only for small, non-protein molecules. Insulin is a protein molecule only half as large as HGH. If it were possible to absorb that kind of hormone by mouth, by spray, or through membranes, millions of people with diabetes would not need to take insulin by injection. The millions of dollars spent on research to do just that has been unsuccessful.

HGH CLAIM: HGH Oral Spray vs. Injections? An injection of one international unit (i.u.) is equivalent to 250,000 nanograms (parts per billion).

HGH FACT: Aproximately 350,000 nanograms (0.375 milligrams) equals one unit of HGH. A 4-unit vial contains approx. 1.52 mg pure HGH (1,520,000 nanograms).

HGH CLAIM: Injected HGH goes into the bloodstream and is absorbed by the liver.

HGH FACT: Some HGH is always taken up by the liver because part of its activity is in the liver. Otherwise, it would be less effective. However, the ultimate distribution of HGH would be exactly the same through oral or nasal tissues by spray (if that were possible) as it is by injection.

HGH CLAIM: Any excess BY INJECTION is destroyed or diluted in the blood.

HGH FACT: The half-life of HGH is only a few seconds after release by the pituitary or by injection. However, it is not destroyed. It must be very rapidly attach to hormone receptors on cells throughtout the body to have its effects. It is not wasted. It attaches to trillions of cells in the body, all types of cells, within a few seconds where it has its benefit. That takes only a few seconds. It is not destroyed, but utilitzed. If HGH does not dilute in the blood to spread throughtout the body, it has no effect.

HGH CLAIM: There is no over stimulation of HGH by the spray.

HGH FACT: This claim makes no sense. HGH does not stimulate HGH, it replaces lost production. The daily production of a 20-year-old is about 500,000 nanograms per day. In a 75-year-old it's about 100,000. The goal is to replace HGH back up to 500,000 nanograms per day.

HGH CLAIM: Compared to the spray, others products are secretagogues, precursors and stimulants, with limited potential for increasing HGH.

HGH FACT: It's true that most products being marketed as nutritional supplements or secretagogues have limited potential for increasing HGH. How a spray can be any different is the unanswered question? Some secretagogues sold as nutritional supplements may be able to increase pituitary HGH release by at up to 30%, if taken in very large doses on a totally empty stomach. A 65-year-old person with only 30% remaining does not get much from a 30% increase (that only increases to less than 40% of a desired level). And, the dose required to do that is quite expensive.

HGH CLAIM: What is HGH Oral Spray made from? This signal messenger hormone is a plant-based all natural product made form microorganisms. There are no animal products used, only HGH and other minerals.

HGH FACT: Then there is no HGH in the product. HGH stands for "human" growth hormone. It exists in no other species of plant or animal.

The Following Have Been Proven By Objective Measurement In Scientific Studies Published In Peer-Reviewed Scientific Journals, But Only With The Injected True HGH:

15% average decrease in fat 8% average increase in muscle and lean body structures Improved skin texture resulting in a more youthful appearance. Skin 7% thicker Fewer skin wrinkles Increased bone density, reversal of osteoporosis Faster healing of any type of injury, fracture or wound Greatly enhanced immunity and resistance to infection Enhanced brain function, retention of intellect with aging Improved sex drive Improvement in overall physical and mental well being Improvement in sleep disorders, better quality of sleep Improved exercise tolerance Improved mineral balance Improved mood, with less depression and fatigue  HGH acts as a master balancer for the body where it regenerates and helps to repair the body with the injected form of HGH in doses of 300,000 nanograms or more per day.

What is Growth Hormone?

Human growth hormone (hGH) is a long chain amino acid molecule produced by the anterior pituitary gland, located at the base the brain. HGH acts on many different tissues to promote healthy metabolism. The bulk of the effect accomplished by hGH is performed by a related hormone called Insulin-like Growth Factor-1 (IGF-1), which is released predominantly by the liver and, to some extent, by other tissues in response to the presence of hGH. It is one of the primary hormones of importance for maintaining optimal cellular performance.

What are the potential benefits of raising Growth Hormone levels?

Natural levels of hGH and IGF-1 decline progressively after young adulthood, leading to many of the bodily changes associated with aging. Raising hGH and IGF-1 levels to those associated with younger physiology slows down or delays the age related decline frequently seen in many organs. Studies reliably demonstrate that the following are among the many beneficial effects of modulating hGH/IGF-1: · Enhanced skin thickness and elasticity · Improved healing time and reduced infection rates after trauma or surgery · Diminished sun damage-type wrinkling · Decreased total body fat · Increased lean muscle mass · Increased bone mineral density · Improved cholesterol profile · Decreased LDL (bad) cholesterol · Increased HDL (good) cholesterol · Improved exercise capacity · Decreased recovery time between workouts · Improved blood flow to the kidney · Improved mood, coping skills, and over-all well-being · Improved general energy levels These effects do not occur over night, after the first several weeks of therapy, the first change that is typically noted is a feeling of enhanced well-being, with most of the compositional changes, such as fat loss or muscle or bone gain noted after 3 to 11 months of therapy.

What are acceptable methods of raising hGh/IGF-1 levels?

There are many companies that promote various pills, elixirs, sprays, or creams that are claimed to contain useful amounts of hGH; they claim that these products are actually taken up by the body through topical, oral, sublingual or nasal administration. One should be skeptical of such claims. It is important to understand that hGH is a very large polypeptide hormone--191 amino acids in exact sequence, maintained in a required three-dimensional shape. The only sources of safe and accurately assembled hGH are those that use recombinant DNA technology that requires elaborate, precise, and monitored methods. There is no equivalent or functional molecule available from any plant or animal source. Similar animal molecules have been shown to be species-specific and unable to mimic the effect of the human molecule.

The Food and Drug Administration (FDA) licenses and oversees companies that manufacture hGH. They must register and verify their methods and product regarding uniformity of quality, bioavailability, safety, and demonstrated effectiveness. HGH may only be administered via injection by prescription under the supervision of a licensed physician through a licensed clinic or pharmacy. Given the above requirements, there are several concerns that arise regarding the claims made by companies not approved by the FDA, that offer hGH products:

1. Only a few companies approved by the FDA to manufacture hGH. Because of the patent parameters, manufacturing hGH is complex and extremely expensive. Any claim that a product contains high would, by federal law, require its production be verified, overseen, and approved by the FDA to meet its standards for quality and content. This creates a double bind for the purveyors of these oral and other form "hGH" products, because if they do contain any significant amount of hGH, it would be illegal to provide it without a prescription, exact content disclosure, or origin of production. The fact that these products do not have to meet the accepted oversight and dispensing standards would indicate that they do not actually contain any significant amount of HGH.

2. Molecules as large as hGH cannot be absorbed into the body across skin or mucous membranes. Even insulin, a molecule only half the size of hGH, and of similar type and construction, cannot be absorbed in this manner. Given this limitation, hGH is digested, or broken down into simpler compounds if it is not injected.

3. There are no published physiologic studies that show any appreciable improvement in systemic hGH/IGF-1 levels achieved with these delivery methods. If it were currently possible, the FDA approved pharmaceutical companies that manufacture hGH (and for that matter insulin) would dearly love to use delivery methods other than injection.

4. Given the expense involved in the manufacture of actual hGH, even if it were to be able to be administered orally or topically, the cost of delivering the proper dose of hGH would be equivalent to the current injection solutions, which have proven very high bioavailability and well demonstrated correlation between dose and subsequent level.

5. HGH is a very fragile molecule; it is dependant upon the retention of a precise complete amino acid sequence and three-dimensional structure, with some parts of the molecule necessarily linked to others. Even under optimal conditions and with refrigeration, can only be stored in solution for two weeks before it loses its function. 6. Products that are shipped and stored at room temperature in uncontrolled or sub-optimal environments cannot retain any functional amount of hGH.

There are only 2 FDA-approved companies which manufacture injectable hGH which can be stored at room temperature for a defined period of time until mixing. Considered as a whole, claims that over the counter or direct-marketed products contain or provide alternate forms of hGH are taking unwarranted advantage of consumer hopes, trust, and lack of medical knowledge. Using authentic claims about the benefits of human Growth Hormone which is injected, furthermore, is highly misleading, as that is not what they are selling.

What About Secretagogues or hGH Precursors?

In the realm of body hormones in general, there are two ways to attempt to augment the amount of a hormone in circulation. The first, as already mentioned, is to give it directly, through injection. The second is to try to stimulate the body in such a way as to increase the amount of hormone that is produced by the body itself, or to enhance the function of hormone that has already been produced. Regarding hGH there are several ways to attempt this:

1) Secretagogues. A secretagogue is a substance that stimulates the pituitary gland to produce hGH. This has been an intriguing avenue of research. Over the last twenty years, several short-chain, orally absorbable compounds have been investigated. Containing as few as three (commonly six to eight) amino acid molecules, some compounds have been shown to stimulate the production of significant amounts of hGH. Of the truly effective molecules, the pituitary gland was stimulated in a too broad manner, and levels of other hormones that are not desirable were also raised.

Most unfortunately, the most common accompanying hormone rise was seen in cortisol levels. In a way, cortisol is the nemesis of hGH, antagonizing the beneficial effects of hGH action. These secondary hormonal changes have severely limited the general role secretagogues may play in hGH supplementation, and have stymied the ability of pharmaceutical research to develop useful compounds. To date, none have proven to be consistent enough in their actions or safety profile to warrant a specific product release. Some claimed secretagogues are available in the over-the-counter market; these products are generally safe, but in general do not demonstrate a certain hGH response in every individual. They seem to have their greatest effectiveness in young (under age 35) and highly athletic people, and require high dose to generate a meaningful response. The number of people who respond is typically around 35%, and in those who respond there is only a 10-30% increases in level.

With advancing age there is a progressively smaller response rate and magnitude of response. Exceptions exist, and it is regarded as a safe category of compound to use in a trial, after a baseline hormone level is established and, after a three- month course of secretagogues, additional retesting of hormone levels is done. A total reevaluation should be made after no more than 6 months to determine effectiveness. Only if there is objective as well as subjective improvement documented should use of the product be continued. Even an FDA approved injectable secretagogue is of limited value even in very young people.

The secretagogue market brings to mind an important caveat regarding any medical or health directed program: The most important aspect of any medical/health undertaking is the open exchange of information; people should know precisely what they put into their bodies. Even patented drugs must disclose what they contain so appropriate decisions can be made regarding safety. Rule number one with secretagogues should be that any marketing company must tell the consumer exactly what he or she is ingesting.

2) HGH Precursors. The concept of hGH precursor use is that if the body is supplied with the constituent parts of hGH, then it may be more apt to decide to use that fortuitous blend of amino acids to more easily make hGH. (Most secretagogue products on the market would really be more accurately placed in this category.)

This effect is seen, but, as above, is limited primarily to young athletic individuals. The most frequent outcome with this approach is no change in hGH level, but with no harm or undesirable hormonal changes. Very high doses may be required, necessitating a gentle approach in patients with decreased renal function, or who are on medications that require excretion by the kidney, especially aspirin related compounds. Response rates can be as low as 10%, with only a small actual rise in hGH levels. Again, response rates and amounts fall with age, and IGF-1 levels should be checked before beginning and after 5-6 weeks, to verify any response. If there is no change, then this intervention should be abandoned.

3) Anti-somatostatin Therapy. There is a concept of therapy that tries to identify compounds or hormones that antagonize the effect of hGH, and tries to foil them. This might be considered the medical equivalent of a double negative or "the enemy of my friend is my enemy". The body produces a hormone called somatostatin. This hormone is the antithesis of hGH. Therapeutic attempts have been made to attack somatostatin function in hopes of freeing the hGH that is already present for a net increase in hGH function or effect. These anti-somatostatin treatments have been intellectually honest but of disappointing effect; typically showing a 1% or so rise in IGF-1 levels, and no measurable clinical difference in patient outcomes. There is no current recommendation favoring the use of these compounds.

The best way to enhance hGH / IGF-1 levels is the direct administration of hGH (Somatropin) via injection.

HGH has positive effects when it comes to the body and it can change a lot in a person from the mental aspect such as the attitude, outlook and expectations from people and society.

It also increases concentration in day to day tasks and acts as an anti depressant for many people. When there is an increase in energy, the person feels more active and also younger.

Dr. Thierry Hertoghe found the following effects of the growth hormone:

Emotional Stability. He found that the growth hormone promotes calmness and people become more confident and also make better decisions under its effect.

Weight Loss. HGH is found to be the most effective when it comes to weight loss. The Growth hormone promotes and increases the metabolism in the human body which in turn leads to reduction of weight and cellulite in boy areas like the abdomen, hips, waist and thighs. A recent study showed that the Human growth hormone made a huge difference in fat composition and the over all body in less than two months in people who were administering it.

Build Muscle.  When body starts secreting its own HGH then you find that there is an increased strength in muscles and it also helps build the muscles in your body. Stamina, vigor, endurance and energy increase.

Improved Memory. It has been found that HGH also helped in increasing memory by rejuvenating the brain cells. Proteins are mainly responsible for storing facts in our brain and HGH directly affected the protein to increase increasing the memory as a result. It was often found through clinical tests that short term memory loss and long term memory loss patients also showed a tremendous decline in HGH production in their body. These people also had a decreased hand to eye coordination.

Elevate Mood. HGH also works like an anti depressant which in turn raises the B-endorphin levels in the brain. This element called the B-Endorphin acts like opium in the brain which helped calm the brain when a human being is faced with extreme stress, agitation, anger or fear. This is released automatically by the human brain as a reaction to the emotions.

Increased sexual Libido. Many people have experienced that their libido and desire for sex has increased after taking HGH injections and supplements.  Men and women claim to have had multiple orgasms after taking HGH. In women menopause, menstrual and post menstrual symptoms also improved by eliminating things like vaginal dryness naturally.

Regulate and Improve Sleep Patterns. Sleep patterns get regulated in people who have a healthy production of HGH. When a person sleeps well in the nights they feel fresh in the morning and well rested. This is very important for the normal functioning of the body. As a person grows old sleeping through the night becomes an impossible task and after taking the growth hormone this condition improved in many people.

Immune System. There was in increase in the production of antibodies which resulted in a better immune system, increased production of T cells and Interleukin 2. These are responsible in multiplying the white blood cells which fight infections.

Improve Brain Function. The brain is a complicated organ and it is made up of some millions of neurons. These neurons are permanent in the brain but once they are dead they never grow back. The human growth hormone has been found helpful in rejuvenating these neurons and also in their repair. The brain is responsible for several activities like learning, memory, understanding and the growth hormone automatically improved all these in a person.

Repair & Protect Cells. 
The growth hormone can act as an anti oxidant and even do things that anti oxidants cannot. Growth factors work alongside vitamins like vitamin C and E are responsible for protecting the cells from decaying. They remove free radicals and harmful enzymes that are responsible for causing cell damage and protect the cells in the body by preventing these enzymes from becoming active.

Bones, Hair & Nails. The growth hormone strengthens the bones, makes the hair more thick, stops the hair from graying, controls cholesterol and blood pressure, improves digestion, increases better breathing, and helps wounds heal faster.

Visit Anti-Aging Group for more information on Bio-Identical Hormone Treatments including Somatropin for Injection, Injectable HGH, Natural Human Growth Hormone Therapies and Supplements ; HGH (Human Growth) News Article: HGH Facts and Information about Human Growth Hormone Therapy & HGH Injections