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Nutraceuticals for Anti-Aging Health

Anti-Oxidant Vitamins for Hormone Health

Mitochondria structures within your body's cells convert the energy from food into a form that your cells can use.  Mitochondria are the cell's energy powerhouses. Mitochondrial supplements help combat oxidative stress and cellular glycation. Aging results from free radical activity, systemic inflammation, DNA damage, advanced toxic lipid and protein glycation in the body.  Mitochondrial Energy Optimizer with Bio-PQQ and CoQ10 help stimulate mitochondrial production, combat DNA damage, free-radicals, lipid and protein glycation.

Oxidative Stress is the steady state level of oxidative damage in a cell, tissue, or organ, caused by the reactive oxygen species (such as free radicals and peroxides).

Glycation the cross-linking of proteins and sugar to form non-functional structures in the body, which can lead to alterations of normal cell function. Mitochondrial Energy Optimizer supplements is designed to counteract age-related structural functional changes; one main ingredient is Carnosine, which is the premier anti-glycation agent.

Omega-3 fatty acids found in Fish Oils, Sesame and Olive Fruit provide many proven heart health and circulatory system benefits including lubricating joints and helping to lower cardiovascular risk. 

Resveratrol is a natural plant extract from the grape berry that has been shown to help in many areas such as being an excellent antioxidant. Resveratrol helps simulate a similar youthful gene expression pattern as calorie restriction, without significant calorie modifications as well as helping with healthy cellular function (also think, Red Wine's health benefits). Fisetin, abundant in strawberries works synergistically with resveratrol to support healthy cell function, neurons and gene expression.

CoQ10 (coenzyme Q10) is required to convert the energy from fats and sugars to usable cellular energy. As we age, our natural levels decline. With ample amounts of CoQ10, mitochondria can work more efficiently in the body including the most densely populated area, the heart. CoQ10 is a potent antioxidant, helping protect proteins, LDL, and DNA of mitochondria from oxidation and supporting mitochondria function.

Cognitex Cognitive Support provides critical extracts that support healthy brain function, such as Vinpocetine which helps with carrying proper amounts of oxygen to the brain. Neuro-Protection complex consisting of rosemary, ginseng, ginger, blueberry extract, pregnenolone and hops - help protect the brain from stress while maintaining youthful cognitive response.

Natural Prostate helps protect the prostate gland and maintain its healthy function. Saw palmetto, Nettle root, Pumpkin seed, Pygeum, Graminex flower, Boron and Lycopene provide anti-inflammatory, anti-estrogen and anti-prostaglandin properties while promoting greater free testosterone in the system and supporting healthy DNA gene function in prostate cells. 

Saw Palmetto has been shown to interfere with DHT activity in the prostate, helps with normal urinary flow as well as helps with inflammatory issues in the prostate.

Triple Action Cruciferous anti-aging formula includes specific extracts anti-oxidant-rich vegetables (broccoli, cabbage, brussels sprouts, watercress, rosemary, cat's claw extract, etc.) that help maintain healthy hormone levels. These supplements include DIM, Apigenin and I3C which supports proper estrogen metabolism, cell protection and protects  the liver against harmful estrogen metabolites.

Milk Thistle is a powerful anti-oxidant that has long been valued for its role in ensuring healthy liver function, prostate and cell protection.

DHEA (Dehydroepiandrosterone) is a naturally occurring hormone that combats aging and promotes longevity. DHEA, like all hormones declines as we age. DHEA benefits include positive effects on mood, body composition, sexuality, bone mineral density, circulatory as well as healthy joint support.

MiraForte formula contains the powerful herb Muira Puama with anti-oxidant and aphrodesian properties. Muira Puama enhances libido, improves sexual function. Chrysin and Nettle Root reduce the level of aromatization, which is the conversion of testosterone to estrogen in the body.This product is excellent for men coming off testosterone therapy to help maintain a higher level of free testosterone in their system.

Call the Anti-Aging Group at 1-800-325-1325 to learn more!

Daily Basic Rx

Daily Basic Rx offers a complete solution to daily supplementation of key nutrients targeting overall health, cognitive support, heart health, and immune support. Each packet contains anti-aging supplements from the MedQuest Pharmacy NUTRAscriptives Rx brand line. These products include our Daily Multiple Rx, Marine Fish Oil Rx, Heart Rx, and Mind Rx. The daily use of these premium supplement formulations offers a complete approach to daily supplementation. Take one packet daily to offer your body all the micro-nutrients and antioxidants needed to support and active healthy lifestyle.

Individual Product Profile

NUTRAscriptives Daily Multiple

Abundant scientific and clinical literature indicates that dietary supplements can play an important role in promoting health and reducing disease. The general public has embraced dietary supplements as an integral part of their daily health program. National surveys report that approximately one-half of adult Americans use supplements on a daily basis. Supplement usage increases with age, income, and education and is more common among women than men. Supplements are also widely consumed by healthcare professionals. Female physicians use supplements at rates equal to those of females in the general population. The Council for Responsible Nutrition reports that 44% of cardiologists, 38% of nurses, 60% of dieticians, and 47% of pharmacy students routinely take supplements. Multivitamin/mineral supplements are the most widely used. With broader use of dietary supplements has come a greater concern about the safety, quality, and appropriateness of these products. One survey conducted by the National Nutritional Foods Association reported that the overwhelming majority of respondents expect to receive information about supplement use from their pharmacists (84%) and physicians (80%). Healthcare providers should be informed about what supplements their patients are taking so as to prevent drug-nutrient interactions and potential toxic levels of some nutrients, and ensure proper, balanced nutritional intake.

Nutritional inadequacies are unfortunately a common occurrence in the U.S. and other industrialized nations because of diets low in fruits and vegetables and high in energy-dense, processed foods. In addition to encouraging healthier food choices, supplementation is recommended when an individual's dietary nutrient intake is inadequate or unbalanced. Levels of nutrient intake at or slightly above the official Recommended Dietary Allowances (RDA) may be adequate to help individuals achieve a more complete and balanced intake of vitamins, minerals and trace elements. However, higher doses in excess of the RDAs may be needed to meet individual requirements that vary with age, level of physical activity, stress, genetic factors, medication usage, toxic burdens, or disease. While RDA levels of intake may prevent overt nutrient deficiencies, chronic nutrient insufficiency may result in altered metabolic activities that lead to physiological dysfunction associated with many common health problems encountered today. Ensuring increased amounts of vitamins and minerals may assist more optimal functioning of interrelated enzyme systems, cellular energy metabolism, hormonal regulation, and detoxification pathways that are critical to maintaining health.

Anti-Aging Ingredient Profile for Daily Multiple Vitamin Supplement

The amounts as well as the forms of each nutrient in Daily Multiple have been selected to help ensure a high degree of nutrient bio-availability, tolerance, and safety with daily, long-term use. A broad spectrum of essential vitamins, minerals, and trace elements is included to take best advantage of the combined synergies and related metabolic functions of these nutrients. Herbal ingredients are not included, thus making this foundation product suitable for most patients without concern over taking inappropriate ingredients. Unlike common, over-the-counter multivitamins, the higher potency amounts of ingredients in Daily Multiple offer greater nutritional benefits. Some of the distinguishing characteristics of Daily Multiple include:

Vitamin A/Carotenoids

Fat-soluble vitamin & antioxidant - Essential for skin, hair, nails and eyesight; helps cells reproduce normally; required for normal reproductive function. Both preformed vitamin A and its carotene precursor are included to help ensure more complete vitamin A nutrition. Diabetics and those with hypothyroidism often have insufficient conversion of beta-carotene to vitamin A, and providing beta-carotene alone may not be sufficient to support immune cell activation. The natural, unsaturated cis form of vitamin A (retinol) from fish liver oil is used instead of the synthetic trans form supplied by vitamin A palmitate. This avoids potential difficulties in absorbing the synthetic form as occurs in individuals with compromised intestinal function. Mixed, natural-source carotenes are used instead of synthetic beta-carotene for more complete antioxidant action.

Vitamin C/Bioflavonoids

Water-soluble vitamin & antioxidant - Causes cells to bind; helps to firm skin, tissue and blood vessels; protects LDL cholesterol from oxidative action; reduces stiffness in arteries and inhibits the clumping of platelets. A buffered, mineral-bound form of vitamin C is utilized to avoid the normal acidity of ascorbic acid to which some individuals may be sensitive. A concentrated source of citrus bioflavonoids complements vitamin C activity.

Vitamin E Complex

Fat-soluble vitamin & antioxidant - Protects cell membranes and other fat soluble tissues; helps the body process glucose; prevents lipid peroxidation. 100% natural vitamin-E complex, including all naturally occurring tocopherol isomers (d-alpha, d-beta, d-gamma, and d-delta) is used for synergistic benefit and balanced actions.

Vitamin D

Fat-soluble vitamin - Maintains calcium in the blood by absorbing calcium from food and urine, allowing the body not to compromise the calcium in the bone; plays a role in immunity and blood cell formation. Natural source vitamin D3 is included at 100% of the recommended daily intake (400 I.U.).

Vitamin B Complex

All B-complex vitamins are included for synergism and balance. Significant amounts of folic acid in its active forms folinic acid and (5-methyltetrahydrofolate), vitamin B6, and vitamin B12 in its active forms (methylcobalamin and S-adenosylcobalamin) are included to assist proper methylation and reduce the risk of toxic build-up of homocysteine.

Thiamine

Water-soluble vitamin (B1) - Aids in the processing of carbohydrates, fats, and protein; needed to form ATP--the fuel the body runs on; helps proper functioning of nerve cells.

Riboflavin

Water-soluble vitamin (B2) - Needed to process amino acids and fats; helps to convert carbohydrates to energy or ATP; acts as an antioxidant.

Niacinamide

Water-soluble vitamin (B3) - Activates enzymes involved in food breakdown; aids in the process of releasing energy from carbohydrates.

Vitamin B-6

Water-soluble vitamin (pyridoxine) - Processes amino acids; an essential nutrient in the regulation of mental processes and mood; aids in protein metabolism/absorption; red blood cell and nerve function.

Folate

Water-soluble vitamin - Necessary for manufacturing DNA and RNA, and for making red blood cells; keeps homocysteine levels in the blood from rising, thereby lowering a heart disease risk; may help lower risks of certain cancers.

Vitamin B-12

Water-soluble vitamin (cobalamin) - nucleic acids - needed for normal nerve cell activity, DNA replication, and the production of red blood cells; aids in lowering homocysteine levels.

Pantothenic Acid

Water-soluble vitamin (B5) - Involved in the kreb's cycle of energy production, needed to make the neurotransmitter, acetylcholine (the memory maker).

Biotin

Water-soluble vitamin (B complex) - Acts as a coenzyme in the metabolism of protein, carbohydrates, and fatty acids.

Mineral/Trace Elements

Fully reacted mineral and trace elements, which are noted for their high bioavailability and tolerance, are used for zinc, magnesium, manganese, copper, and several other minerals. Organically bound forms of chromium and vanadium are included for high physiological activity of these trace elements. Iron is not included since most adults (men and post-menopausal women) do not require supplemental amounts of this mineral which may be a potentially harmful pro-oxidant.

Calcium

Mineral - The most abundant mineral in the body; is needed to form strong bones and teeth; required for proper nerve function and muscle contraction; essential for blood clotting.

Iodine

Mineral - Needed to make the thyroid hormones, which maintain normal metabolism in all cells of the body.

Magnesium

Mineral - Needed for tendon, muscle, and bone structure; helps lower blood pressure; activates the B vitamins; helps form ATP.

Zinc

Mineral - Is a component of more than 300 enzymes involved in wound repair; boosts immunity; battles free radicals; helps cells reproduce; aids in the preservation of vision.

Selenium

Mineral - Activates an antioxidant enzyme glutathione peroxidase, which helps protect the body from cancer; essential for healthy immune functioning by stimulating white blood cells; assists vitamin E in preventing breakdown of fats.

Manganese

Mineral - Needed for healthy skin, tendon, cartilage, and bone formation; necessary for glucose tolerance; helps activate superoxide dismutase (SOD).

Chromium

Mineral - Helps the body maintain normal blood sugar levels; increases HDL (good) cholesterol and lowers total cholesterol levels; has a potential role in positively altering body composition.

Molybdenum

Mineral - Essential in the metabolism of iron. Potassium - Mineral - Regulates water balance, levels of acidity, and blood pressure; aids in nerve transmission and metabolism.

Inositol

Mineral - Required for proper formation of cell membranes. It aids in nerve transmission and helps transport fats within the body.

NUTRAscriptives Mind Rx

13 key neuronutrients for cognitive function.

This formulation is a prime example of why we emphasize a coordinated, multinutrient approach whenever possible to promote maximum benefit and safety. The brain's complex metabolism requires many different nutrients for optimum cellular communication and a balanced response to stress. Excessive or chronic release of adrenaline and cortisol, accumulated effects of toxins, and impeded flow of oxygen and nutrients can damage the brain and disrupt mental alertness, memory, and other functions. While using one or two neurosupportive nutrients can help target specific areas of function, care is needed to avoid potentially harmful effects of over stimulating only one neurotransmitter pathway. The ingredients in Mind Rx were chosen for their complementary and documented roles in neuronutrition and are supported by other key neuronutrients in the Daily Multiple vitamin/mineral formula. Used daily, this combined spectrum of nutrients may improve absentmindness and other mild memory problems associated with aging.

Numerous age-related changes take place in neuronal and behavioral function, even in the absence of neurodegenerative disease. These include impairment of brain microcirculation, alterations in neurotransmitter synthesis and function, imbalance in hormonal function in response to chronic stress, and free radical-induced damage to nerve cell membranes and metabolic activities. As a result, most individuals over the age of 40 experience some decline in memory retention, concentration, and acuity. This is technically referred to as Age-Related Cognitive Decline (ARCD) or Age-Associated Memory Impairment (AAMI).

Recent research strongly suggests that numerous dietary components can impede and, in some cases, reverse the course of deleterious neuronal aging. Normal age-related decline in cognitive function is characterized by decreased concentrations of multiple chemical transmitters. Thus, excessive activation of just one or a few pathways may result in an undesirable imbalance in nerve cell communication and brain function. Because optimal brain function is dependent upon the multiple neurotransmitter networking profile, the following nutrients in Mind Rx have been selected to help the body produce and maintain a proper balance of the different neurotransmitter pathways to support healthy mental capacity.

Anti-Aging Vitamin Ingredient Profile for Nutrascriptives Mind RX

Acetyl-L-Carnitine

Acetylcholine is a principal neurotransmitter involved in memory and learning. Cholinergic function declines with aging and may be due to loss of nerve cells in learning and memory areas, a decline in neurotransmitter output, or a combination of both. Aging is also associated with a decline in the production of nerve growth factor (NGF) and the number of NGF receptors. Acetyl-L-carnitine, the acetylated ester of the amino acid L-carnitine, has been demonstrated to increase the synthesis and release of acetylcholine, retard and partially reverse the loss of neurons from the hippocampus and prefrontal cortex, and partially reverse the negative changes in NGF metabolism. Acetyl-L-carnitine also increases cerebral blood flow in patients with cerebrovascular disease. The L-carnitine moiety is essential for the transport of long-chain fatty acids into nerve cell mitochondria where they serve as a primary fuel for cellular energy production. It also helps maintain the bound-to-free coenzyme A (CoA) ratio and removes toxic concentrations of acetyl-CoA within the mitochondria, thereby helping to ensure that energy production can continue. Due to its central role in energy metabolism, L-carnitine is especially needed to support tissues such as brain, which have a high-energy requirement.

L-Glutamine

A conditionally essential amino acid, L-glutamine serves as a major precursor molecule to the synthesis of two important neurotransmitters: the excitatory L-glutamic acid and the inhibitory gamma-aminobutyric acid (GABA). Glutamate also plays an important role in secondary metabolic functions in the neocortex where it assists detoxification of ammonia and serves as a building block of proteins.

L-Pyroglutamic acid

L-Pyroglutamic acid, a natural glutamate metabolite, increases acetylcholine release, cerebral blood flow, and brain metabolism. It stimulates cholinergic nerve cell metabolism by increasing the uptake and utilization of glucose while at the same time decreasing brain lactate dehydrogenase activity, thus enhancing anaerobic glycolytic activity. Blocking of glutamate receptors by L-pyroglutamic acid stimulates acetylcholine release in cortical cells. This causes GABA levels to rise, followed by cortical acetylcholine release.

L-Tyrosine

This non-essential amino acid is used by the brain to make catecholamine neurotransmitters including dopamine, norepinephrine, epinephrine, and L-DOPA. Norepinephrine has a general energizing effect while elevating mood, countering stress, and contributing to short-term memory and concentration. Dopamine also helps elevate mood and is the principal neurotransmitter involved in central nervous system control of muscle movement. Tyrosine has been reported to improve mental function that may be impaired by stress, sleep deprivation, and depression.

Dimethylaminoethanol (DMAE)

Dimethylaminoethanol is a naturally occurring compound produced in small amounts in the brain. Studies show that exogenous DMAE results in increased levels of choline in the blood and brain. However, unlike choline itself, DMAE crosses the blood-brain barrier more effectively, enabling it to reach the brain and increase choline levels more efficiently. The increased availability of choline in the brain is believed to speed the production of acetylcholine, a crucial neurotransmitter involved in memory, learning, recall and thought processes.

Ashwagandha (Withania somnifera)

This Ayurvedic herb exerts an anti-stress neuroprotective effect. This may be due to its antioxidant action and the ability to decrease stress-induced cortisol release. Cortisol interferes with the brain's supply of glucose and neurotransmitter function, and causes excessive influx of calcium that, over time, produces increased free radical formation leading to nerve cell damage and death. Ashwagandha extract also increases cortical cholinergic activity thus contributing to an enhancement of memory and cognition.

Blueberry (Vaccinium corymbosum) Extract

Polyphenolics, such as found in blueberries, exert potent antioxidant protection against oxidative stress in the central nervous system. Neurons become increasingly susceptible to oxidant damage with age, which may contribute, at least in part, to neurodegenerative changes. Considerable evidence exists showing that antioxidants neutralize free radicals and the consequent oxidative damage that they generate and may produce a slowing down or even a reversal of age-related declines in neuronal signaling and cognitive performance. Polyphenolics found in blueberry extract are among the most effective agents that neutralize free radical activity. Rats fed blueberry extract show significant reversals in neuronal signal transduction, cognitive, and motor deficits.

Ginkgo Biloba

Numerous studies support the effectiveness of Ginkgo biloba extract for improvement of cognitive function and memory. Two groups of compounds, ginkgo flavone glycosides and terpene lactones, are considered to be the primary active constituents. These are responsible for enhancing cerebral microcirculation through a relaxing effect on vascular walls and an anti-platelet aggregation activity. This produces an increased delivery of oxygen to nerve cells that facilitates glucose utilization and enhancement of memory and cognitive functions. Besides improving circulation, the glycoside and lactone constituents prevent oxidative damage to nerve cell membranes, mitochondria, and biochemical processes by suppressing the production of active nitrogen and oxygen reactive species and thereby producing an anti-inflammatory effect. Ginkgo is reported to enhance cholinergic activity by inhibiting age-related loss of acetylcholine receptors and stimulating choline uptake in hippocampal neurons.

Eleuthero (Eleutherococcus senticosus)

Like ashwagandha, Eleuthero is reported to protect the brain by helping to reduce stress-induced release of cortisol. This occurs, at least in part, through an inhibition of enzymes that limit the binding of stress hormones to their receptors.

Vinpocetine

Vinpocetine, derived from vincamine, a compound found in the leaves of the periwinkle plant, has been widely used in Europe for many years to aid memory and support healthy brain function. It has been shown in numerous studies to exert its benefit on the brain through several mechanisms of action. Cerebral blood flow is increased through cyclic GMP-induced myorelaxation producing regional vasodilation, normalization of erythrocyte flexibility, and inhibition of platelet aggregation. Oxygen uptake by nerve cells is increased, thereby reducing damage caused by hypoxic conditions. Mitochondrial respiratory rate is increased in mitochondrial suspensions. This may act to increase glucose utilization and the rate of ATP production thus enhancing overall brain energy levels. Vinpocetine also acts as an antioxidant, preventing the formation of reactive oxygen free radicals and lipid peroxidation in synaptosomal preparations.

GlyceroPhosphoCholine (GPC)

GPC has been extensively researched for its brain benefits. Supplementation with GPC has been shown in numerous clinical studies to significantly benefit attention, mental focus, recall and other higher mental functions in young, middle aged and elderly subjects. In addition to being a normal metabolic precursor of acetylcholine, GPC also acts as a precursor to phosphatidylcholine, the most common phospholipids in nerve cell membranes. Therefore, GPC's vital role to both the individual nerve cell and their electrical integration via acetylcholine production may account for its impressive spectrum of clinical benefits.

Phosphatidylserine

Phosphatidylserine exerts a restorative effect on memory via several different, but complementary actions. It corrects age-related cholinergic deficiency by increasing the availability of choline for acetylcholine synthesis and correcting the decline in cholinergic receptors. It helps maintain nerve cell membrane fluidity thus allowing for efficient transport of compounds, including glucose and other needed nutrients, both within and across the membrane in various brain regions. And, it helps balance the neuroendocrine response to stress characterized by the excessive release of ACTH, cortisol, and adrenaline.

Normal age-related cognitive decline may also be related to inadequate nutrient intake and antioxidant protection. Critical nutrients include the B-vitamins, vitamins C and E, magnesium, selenium, zinc, and chromium. Thus, it is recommended that Mind Rx be taken with a Daily Multiple vitamin/mineral/trace element supplements to achieve more comprehensive nutritional and antioxidant support for maintaining and improving concentration, learning, and memory.

NUTRAscriptives Heart Rx

Heart disease is wrought by common influences in our modern day society. Look around you. What kind of food is easy to buy and make? What types of foods can you conveniently get in a drive-thru? When was the last time you broke into a true sweat? What's your stress level at home and work? If you're like most Americans, you will answer the aforementioned questions in this order—instant rice and macaroni and cheese; hamburger and fries; when I was a kid playing kissing tag on the playground; and I can't remember a time when I wasn't stressed. Our lifestyles are not very heart friendly, neither are they easy to modify. Most of us are rushed through our meals, too exhausted to exercise, and stressed beyond belief. Cardiovascular disease affects millions of people in the United States (one out of five Americans have high blood pressure) and the principle reasons behind this epidemic are easily taken care of with the right diet and exercise regimen. MedQuest Pharmacy has also created a Heart Formula to add to a heart-healthy exercise and diet program. Many supplements have been shown in clinical studies to prevent heart conditions as well as being used therapeutically to treat certain heart ailments. We have combined what we believe are the best and most efficacious ingredients in keeping your heart in a healthy rhythm with the rest of your hectic life.

Vitamin Deficiency Symptoms:

Several of the ingredients in the Heart Formula are necessary constants in the human body and in their absence the body, and specifically the heart, cannot function properly.

Ingredient Profile

Alpha Lipoic Acid

Termed the “universal antioxidant,” alpha lipoic acid has a wide range of activities in the human body. Found in every cell, this jack-of-all-trades helps synthesize glucose to energy. In this respect it can reduce insulin resistance by increasing the cellular uptake and oxidation of glucose. As an antioxidant alpha lipoic acid has the unique ability to function in both water and fat—giving it a gamut of antioxidant action. Lipoic acid also works as a recyclable receptacle, regenerating and extending the metabolic life of other antioxidants in the body, like vitamins E and C. It's truly an amazing substance. Several studies have shown that alpha lipoic acid significantly reduces myocardial lipid peroxidation. Other reports have shown that alpha lipoic acid can treat diabetic peripheral neuropathy, a condition in which nerves leading to the arms and legs are damaged.

Coenzyme Q10 (CoQ10)

A powerful nutrient, which is vital to our very existence, CoQ10 is found in every cell of the human body. Research has found that it is absolutely essential to the heart's survival, however, the bad news is that as we get older, our CoQ10 levels decline, especially in our heart. And if you're on a statin, you may want to take note: Statins, meant to secure your heart's safety, may be doing just the opposite. Research is finding that these cholesterol-lowering drugs may also be lowering your levels of Coenzyme Q10. Grape Seed Extract: Oligomeric proanthocyanidins (OPCs) found in wine and grape juice are getting reviews from researchers everywhere as heart healthy compounds. Stroke is the third leading cause of death in the United States and the most common form, ischemic stroke, takes place when blood flow in the brain is disturbed by a blood clot. A recent study in Stroke showed that two glasses of wine a day could lower a young woman's risk of suffering an ischemic stroke by 40 to 60 percent. Another recent study showed that grape juice was able to protect LDL from oxidation.

Hawthorn Extract

Dating back to the time of Nero, hawthorn has been the old faithful remedy for the heart. Like taurine, evidence indicates that hawthorn improves the heart's pumping ability in congestive heart failure. Hawthorn has also been shown to lower blood pressure at low, but effective dose.

L-Taurine

One of the most abundant amino acids in the body, L-taurine is believed to regulate heart beat, maintain cell membranes and affect the release of neurotransmitters in the brain. Hypertension, a condition that puts arterial blood under extreme pressure, affects almost 50 percent of the United States. Research has shown that L-taurine may help control blood pressure by normalizing the increased nervous system activity often associated with high blood pressure and inciting a beta-endorphin response that relaxes the blood vessels. Preliminary research has shown that L-taurine may be protective in congestive heart failure, a condition in which the heart has trouble pumping blood.

NUTRAscriptives Marine Fish Oil Rx

Respected medical journals like The New England Journal of Medicine and Circulation have reported on the ever-growing list of benefits from a high intake of the essential fatty acids found in fish oil. Experts have found that fish oil may help the heart by lowering total serum cholesterol, elevating HDL (good) cholesterol, decreasing triglycerides, lowering blood pressure, and reducing platelet aggregation. Beyond heart health, fish oil may boost mental and emotional function, treat arthritis and other inflammatory disorders, improve dry skin conditions and acne, decrease headaches and enhance mood. With the highest-potency ultra-pure fish oil containing over 70% omega-3 fatty acid content. This product supplies extra-strength amounts of both EPA and DHA to allow for maximum intake of omega-3s in the fewest number of soft gel capsules. This exceptionally pure fish oil concentrate undergoes molecular distillation and a series of other refining processes to ensure that it is essentially free from heavy metals, dioxins, and PCBs. Each batch is third party tested to guarantee to be sure that it meets the strictest quality standards for freshness and purity. Added vitamin E and rosemary serve as antioxidants to protect the lipid components from oxidation. Natural lemon flavor provides a light citrus taste.

Following is a description of the process method used for the preparation of the Marine Fish Oil Rx.

Processing

An unique multi-step process is employed for producing concentrated Omega-3 fish oils that ensures only the purest, cleanest, most effective products on the market.

• Raw material access and control: The manufacturer has direct access to the best fisheries in the world for manufacture of Omega-3 fish oil. At the time of harvest, we actively select the species and grade of raw material that will yield the optimal level of EPA & DHA in our finished products. Species selected include deep marine sardine, mackerel and anchovy.
• Extraction: Removes raw oil from the fleshy meat of the fish.
• Winterization: Removes saturated fats present in the raw oil, leaving a clear-colored oil with more long-chain fatty acids and no saturated fat.
• Deodorization: Removes heavy metals, PCBs and other unwanted elements for cleaner, scent-free oil with no aftertaste.
• Molecular distillation: Completely refines the oil and ensures removal of man-made pollutants such as PCBs in both standard and concentrated oils.
• Completion: The result is the purest Omega-3 fish oil on the market. Every batch is put through more than 50 in-process and final quality checks before it is shipped to our clients. This includes a comprehensive independent laboratory analysis of the encapsulated product including fatty acid profile, heavy metal, other contaminants, and peroxide value.

Ingredient Profile & Activity

Eicosapentaenoic acid (EPA) & Docosahexaenoic acid (DHA):

Omega-3 Fatty Acids & Reduction of Cardiovascular Disease Events

Inuit people in northern Canada and Alaska consuming their customary fish-rich diet have low death rates due to cardiovascular disease. The same observation holds true for Japanese eating a traditional seafood-rich diet. Most, but not all, large cohort studies have found that fish consumption is associated with a reduction in general (all cause) death rates and in cardiovascular events such as heart attack. The largest relative risk reduction of cardiovascular disease outcomes has been found in studies reporting on fish consumption and the incidence of sudden cardiac death. Compared to placebo, omega-3 fatty acid supplementation for two years was associated with modest improvements in coronary artery blocking plaque as assessed by arteriography in patients with coronary artery disease. Another study randomized patients awaiting carotid artery surgery (endarterectomy) to fish oil, sunflower oil or placebo and assessed the morphology of the plaque removed from the carotid at surgery. Omega-3 fatty acids were incorporated into the plaque in the patients receiving fish oil and resulted in thicker, fibrous plaque caps and less inflammatory infiltrate. These findings suggest that omega-3 fatty acids may decrease arterial plaque burden and facilitate formation of more stable plaque less likely to rupture resulting in heart attack or stroke.

Omega-3 Fatty Acids & Risk Reduction after Heart Attack/dt>

Among the first studies to assess the protective effects of omega-3 fatty acids from fish after heart attack was the diet and reinfarction trial (DART). It found that increased fatty fish consumption was associated with a 29% reduction in all cause mortality at 2 years after heart attack. The largest trial yet published on the fish oil mediated reduction of death rate following heart attack involving over 11,000 patients with a recent heart attack is the Italian GISSI-prevention study. This study found that 1 gram daily of fish oil (850 mg of EPA and DHA as ethyl esters) resulted in a 15% reduction in the aggregate end point of total death, non-fatal recurrent heart attack and non-fatal stroke. Secondary analyses showed that fish oil reduced the risk of cardiac death by 30% and the risk of sudden cardiac death by 45%. A meta-analysis of 10 randomized, controlled trials involving over 14,000 patients with a daily intake of omega-3 fatty acids for a mean duration of 37 months found that fish oil decreased mortality from all causes by 16% and reduced the incidence of death due to heart attack by 24%.

Omega-3 Fatty Acids & Arrhythmias

Fish oil has its greatest cardiovascular impact by reducing the risk of sudden cardiac death, which is nearly always due to a ventricular arrhythmia. Four prospective, randomized clinical trials have found that fish oil or other interventions to boost intake of omega-3 fatty acids is associated with a reduced risk of sudden death. In addition to ischemia-induced ventricular arrhythmias, omega-3 fatty acids have been found to reduce the incidence of atrial arrhythmias and have been suggested as a possible treatment for atrial fibrillation. Omega-3 polyunsaturated fatty acids have been found to have significant arrhythmic properties. Omega-3 polyunsaturated fatty acids protect against ischemia-induced ventricular arrhythmias in both dog and rat models. Basic research has shown that omega-3 fatty acids electrically stabilize the cardiac myocyte by modulating membrane (sarcolemma) ion channel conductance, especially the voltage-dependent sodium current and the L-type calcium channel. Omega-3 fatty acids affect the membrane bilayer microdomain in juxtaposition to the ion channels and directly affect the ion channel. However, in people with a history of ventricular tachycardia or fibrillation, implantable cardiac defibrillators and significant left ventricular pump dysfunction, fish oil may increase the risk of ventricular arrhythmias, especially ventricular tachycardia.

Omega-3 Fatty Acids & Lipids

EPA and DHA have consistently been shown to reduce triglyceride levels. A meta-analysis of 36 crossover and 29 parallel design studies found that fish oil omega-3 fatty acids decrease serum triglyceride concentrations by 25-30%. Fish oil was found to increase low-density-lipoprotein (LDL) cholesterol concentrations by 5-10% and high-density-lipoprotein (HDL) cholesterol by 1-3%. Lipid subfraction analysis suggests that although fish oil may increase LDL, the increase is in the larger, less dense, less atherogenic LDL fraction and not in the smaller, more atherogenic fraction. High doses of DHA (4 g/day) have been found to increase HDL2, a more cardioprotective HDL fraction. Omega-3 fatty acids appear to provide support for a cardioprotective lipid profile.

Omega-3 Fatty Acids & Endothelial Dysfunction

Endothelial dysfunction reflects an imbalance between vasoconstriction and vasodilation and is observed in people with high cholesterol levels, high blood pressure, diabetes, atherosclerotic vascular disease and aging. It may be a critical early event in the development of atherosclerosis and cardiovascular disease. Serum EPA and DHA levels are inversely associated with indicators of endothelial dysfunction. Long-term treatment with EPA is known to improve impaired endothelialdependent relaxation of blood vessels in animals and humans. Omega-3 fatty acids cause endothelial relaxation and increase arterial compliance. They lower blood pressure in people with both normal and high blood pressure.

Omega-3 Fatty Acids & Mental Health

One out of every three fatty acids in the central nervous system is a polyunsaturated fatty acid. Omega-6 arachidonic acid and omega-3 DHA are the major polyunsaturated fatty acids found in the brain. DHA affects membrane fluidity, excitability and synaptic function. Several studies have assessed the use of omega-3 fatty acids to treat major depression and bipolar disorder. A study of patients with persistent depression despite standard medication found that 1 g/day of EPA improved depression scores compared to placebo. But, 2 g/day of EPA had no benefit. However, another study did find that 2g/day of EPA significantly reduced Hamilton depression scores in medicated patients with persistent depression. A small, short-term pilot study in patients with bipolar disorder revealed that high-dose (9.6 g/day) omega-3 fatty acids stabilized mood and prolonged remission compared to placebo. Omega-3 fatty acids may be beneficial for people suffering from schizophrenia. In symptomatic schizophrenic patients on stable antipsychotic medication, 2 grams EPA, but not DHA, significantly improved disease severity scores compared to placebo. In a second study, 2 g/day EPA for 3 months as a sole treatment for schizophrenia made disease severity scores significantly better.

Omega-3 Fatty Acids & Neurological Disorders

Given the importance of omega-3 fatty acids, especially DHA, in brain and nerve metabolism, the effect of fish and fish oil consumption on neurological disorders has been evaluated. Three studies have assessed the effect of omega-3 fatty acids on the incidence of dementia. In only one of these three studies was fish intake associated with a significant decrease in the incidence of non-Alzheimer's dementia. All three studies found that fish intake reduced the risk of developing Alzheimer's disease, but the finding was statistically significant in only one study. Total omega-3 and DHA consumption, but not alpha-linolenic acid or EPA intake, significantly reduced the incidence of Alzheimer's disease. DHA has been found to cause a small improvement dementia rating scores in people with established Alzheimer's disease. The promise of DHA for the prevention and even treatment of dementias, especially Alzheimer's disease, remains to be explored. The role of omega-3 fatty acids in other neurological disorders appears less promising except for multiple sclerosis. One study has found that fish consumption was associated with a lower risk of developing multiple sclerosis. Two studies have found no link between omega-3 fatty acid intake and the incidence of multiple sclerosis. Two of three studies have reported that omega-3 fatty acids significantly reduce disability and improve an index of disease progression in patients with multiple sclerosis.

Omega-3 Fatty Acids & Eye Health

The eye is greatly enriched with omega-3 fatty acids that accumulate during late fetal development and early after birth. Very high levels of DHA are present in the retina especially in the outer portions of photoreceptor cells. DHA may facilitate the dynamics of the light absorbing pigment, rhodopsin. An ample dietary supply of omega-3 fatty acids appears to be essential for the optimal development of vision. Children age 6 to 12 months supplemented with DHA (130 mg/day) developed significantly better visual acuity than did children fed a control diet. Unfortunately, the possible role of omega-3 fatty acids in supporting eye health has not been well examined. Studies on the effect of fish consumption and the risk of age-related macular degeneration (ARMD) have yielded conflicting results. One prospective cohort study found that fish intake did not protect patients against progression to advanced ARMD. Inconclusive studies suggest omega-3 fatty acids may slow progression in patients with retinitis pigmentosa. Meaningful research on omega-3 fatty acid intake and eye health remains to be done.

Omega-3 Fatty Acids & Skin Health

Human skin is constantly exposed to internal and external factors that may lead to photoaging, inflammation, immune dysfunction, imbalanced epidermal homeostasis or other skin disorders. Several studies have found large doses of fish oil appear to be photoprotective. Omega-3 fatty acids in relatively low doses (60 to 75 mg of fish oil containing 180 mg EPA and 120 mg DHA per gram) have been found to reduce erythema, scaling, and itching in patients with psoriasis. In one study of people with severe psoriasis, 12 g/day of EPA reduced redness and scaling in 8 of 10 people. Doses of 1.8 g daily of EPA in people with moderate to severe atopic dermatitis reduced itching and scaling after 12 weeks in a placebo-controlled trial. More studies are needed to fully elucidate the effects of fish oil on skin function, nevertheless omega-3 fatty acids appear important for maintaining healthy skin.

Omega-3 Fatty Acids & Asthma

Inflammation is important in the development of asthma. An imbalanced omega-6 to omega-3 fatty acid dietary ratio promotes inflammation and may contribute to the increased prevalence of asthma. Although short-term trials with fish oil have found no effect on asthma symptoms, longterm studies have found fish oil effective. A 10-month study using 84 mg of EPA and 36 mg DPA in children with bronchial asthma improved asthma scores and increased acetylcholine response thresholds. Another study found supplementing with 3.2 g EPA and 2.2 g DHA for 3 weeks improved post-exercise lung function in people with exercise-induced asthma. EPA and DHA also significantly decreased levels of inflammatory mediators such as leukotriene E4, TNF alpha, and IL-1beta. Diets enriched with EPA and DHA omega-3 fatty acids may prove to be supportive of normal lung function in people with asthma.

Complete Nutritional Potential

Daily Basic Rx provides key nutrients and antioxidants that help support the body in numerous areas of metabolic function as summarized below.

• Cellular Antioxidant Protection: Alpha Lipoic Acid, Beta-carotene, Blueberry extract, Coenzyme Q10, Grape Seed Extract, Selenium, Hawthorn Extract, L-Taurine, Vitamin C, Vitamin E plus mixed tocopherols
• Cardiovascular Function: EPA, Magnesium, Potassium, Selenium, Vitamin E
• Cognitive Function: Acetyl-L-Carnitine, Ashwagandha extract, Blueberry extract, DHA, DMAE, Eleuthero, GPC, L-Glutamine, L-Pyroglutamic acid, L-Tyrosine, Phosphatidylserine, Vinpocetine
• Nervous System Support: Calcium, Choline, Magnesium, Vitamin B1, B6, B12 Heart Health: Alpha Lipoic Acid, Coenzyme Q10, EPA, Grape Seed Extract, Hawthorn Extract, L-Taurine
• Homocysteine Regulation: Folinic acid, 5-methyltetrahydrofolate (5-MTHF), Vitamin B6, B12
• Visual Function: Vitamin A with mixed carotenoids, Zinc
• Bone Health: Boron, Calcium, Magnesium, Manganese, Vitamin D, K
• Connective Tissue Support: Bioflavonoids, Copper, EPA, Manganese, Vitamin C, Zinc
• Blood Glucose Regulation: Biotin, Chromium, Niacinamide, Manganese, Vanadium
• Energy Metabolism: Iron, L-Glutamine, Magnesium, Niacin, Pantothenic acid, Vitamin B1, B2
• Adrenal Gland Function: Pantothenic acid, Vitamin C
• Immune System Enhancement: EPA, Selenium, Vitamin A, C, E, Zinc
• Capillary Integrity: Bioflavonoids , Vitamin C
• Cholesterol Metabolism: Chromium, EPA, Niacin, Vanadium, Vitamin C, E
• Thyroid Function: Copper, Iodine, Selenium